 | Robin Williams
Popeye |
 | Shelley Duvall
Olive Oyl |
 | Ray Walston
Poopdeck Pappy |
 | Paul Dooley
Wimpy |
 | Paul L. Smith
Bluto |
 | Richard Libertini
Geezil |
 | Donald Moffat
The Taxman |
| MacIntyre Dixon
Cole Oyl |
 | Roberta Maxwell
Nana Oyl |
 | Donovan Scott
Castor Oyl |
| Allan F. Nicholls
Rough House |
| Wesley Ivan Hurt
Swee'pea |
 | Bill Irwin
Ham Gravy, the Old Boyfriend |
 | Robert Fortier
Bill Barnacle, the Town Drunk |
 | David McCharen
Harry Hotcash, the Gambler |
| Sharon Kinney
Cherry, His Moll |
| Peter Bray
Oxblood Oxheart, the Fighter |
 | Linda Hunt
Mrs. Oxheart, his Mudder |
| Geoff Hoyle
Scoop, the Reporter |
 | Wayne Robson
Chizzelflint, the Pawnbroker |
| Larry Pisoni
Chico, the Dishwasher |
| Carlo Pellegrini
Swifty, the Cook |
 | Susan Kingsley
La Verne, the Waitress |
| Michael Christensen
Splatz, the Janitor |
 | Ray Cooper
The Preacher |
| Noel Parenti
Slick, the Milkman |
| Karen McCormick
Rosie, the Milkmaid |
 | John E. Bristol
Bear - the Hermit (as John Bristol) |
 | Julie Janney
Mena Walfleur - a Steinette |
| Patty Katz
Mina Walfleur - a Steinette |
| Diane Shaffer
Mona Walfleur - a Steinette |
| Nathalie Blossom
Blossom Walfleur - a Steinette |
 | Dennis Franz
Spike, a Tough |
 | Alan Autry
Slug, a Tough |
 | Ned Dowd
Butch, a Tough |
| Hovey Burgess
Mort, a Tough |
 | Roberto Messina
Gozo, a Tough |
 | Pietro Torrisi
Bolo, a Tough |
| Margery Bond
Daisy, a Housewife |
| Judy Burgess
Petunia, a Housewife |
| Saundra MacDonald
Violet, a Housewife |
| Eve Knoller
Min, a Housewife |
| Peggy Pisoni
Pickelina, a Housewife |
| Barbara Zegler
Daphne, a Housewife |
| Paul Zegler
Mayor Stonefeller, the Official |
| Pamela Burrell
Mrs. Stonefeller |
| Klaus Voormann
Von Schnitzel, the Conductor |
| Doug Dillard
Clem, the Banjo Player |
| Van Dyke Parks
Hoagy, the Piano Player |
| Stan Wilson
Oscar, the Barber |
| Valerie Velardi
Cindy, the Drudge |
 | Jack Mercer
Popeye - Animated Prologue |